|Population biology of Pseudomonas aeruginosa|
For P. aeruginosa there were more than a thousand different clonal complexes identified, the majority of which are rare [Wiehlmann et al., 2007; Selezka et al., 2012]. Just 20 clones make up about 40% of the contemporary population. Members of the two major clones C [Römling et al., 2005] and PA14 [Rahme et al., 1995] were sampled from salt and fresh water, secluded national reserves, anthropogenically polluted sites, plants, wild and domestic animals and acute and chronic human infections. In other words, these two global clones are everywhere. However, the 20 next frequent clones predominate in particular geographic areas and/or habitats. Numerous clones still have no representative among the subset of human infections and, conversely, clones that had previously caused outbreaks of nosocomial infection still lack an environmental isolate in our strain collection. These data suggest that the P. aeruginosa population consists of global and local generalists on the one hand and niche specialists on the other.
Widespread geographic distribution of major P. aeruginosa clones. Clones are depicted by uppercase letters and are arranged by decreasing frequency in alphabetical order.
Wiehlmann L, Wagner G, Cramer N, Siebert B, Gudowius P, Morales G, Köhler T, van Delden C, Weinel C, Slickers P, Tümmler B.
Population structure of Pseudomonas aeruginosa.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8101-6.
Selezska K, Kazmierczak M, Müsken M, Garbe J, Schobert M, Häussler S, Wiehlmann L, Rohde C, Sikorski J.
Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure.
Environ Microbiol. 2012 Aug;14(8):1952-67.
Römling U, Kader A, Sriramulu DD, Simm R, Kronvall G.
Worldwide distribution of Pseudomonas aeruginosa clone C strains in the aquatic environment and cystic fibrosis patients.
Environ Microbiol. 2005 Jul;7(7):1029-38.
Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM.
Common virulence factors for bacterial pathogenicity in plants and animals.
Science. 1995 Jun 30;268(5219):1899-902.